Spatial patterns in the evolution of Cenozoic dynamic topography and its influence on the Antarctic continent

Our knowledge of dynamic topography in Antarctica remains in an infancy stage compared to other continents. We assess the space-time variability in dynamic topography in Antarctica by analysing grids of global dynamic topography in the Cenozoic (and late Cretaceous) based on the tomographic model S40RTS. Our model reveals that the Gamburtsev Province and Dronning Maud Land, two of the major nucleation sites for the East Antarctic Ice Sheet (EAIS) were ~500 m higher 60 Ma ago. The increased elevation may have facilitated ephemeral ice cap development in the early Cenozoic. Between ca 25 and 50 Ma the northern Wilkes Subglacial Basin was ca 200 m higher than today and a major increase in regional elevation (>600 m) occurred over the last 20-15 Ma over the northern and southern Victoria Land in the Transantarctic Mountains (TAM). The most prominent signal is observed over the Ross Sea Rift (RSR) where predicted Neogene dynamic topography exceeds 1,000 m. The flow of warm mantle from the West Antarctic Rift System (WARS)may have driven these dynamic topography effects over the TAM and RSR. However, we found that these effects are comparatively less significant over the Marie Byrd Land Dome and the interior of the WARS. If these contrasting dynamic topography effects are included, then the predicted elevations of the Ross Sea Embayment ca 20 Ma ago are more similar to the interior of the WARS, with significant implications for the early development of the West Antarctic Ice Sheet

A high-resolution aeromagnetic field test in Friuli: towards developing remote location of buried ferro-metallic bodies

High Resolution AeroMagnetic surveys (HRAM) are a novel tool experimented in several countries for volcano and earthquake hazard re-assessment, ground water exploration and mitigation, hazardous waste site characterization and accurate location of buried ferrous objects (drums, UXO, pipelines). The improvements achieved by HRAM stem from lower terrain clearance coupled with accurately positioned, real-time differential navigation on closely spaced flight grids. In field cultural noise filtering, advanced data processing, imaging and improved interpretation techniques enhance data information content. Development of HRAM approaches might also contribute to mitigate environmental hazards present throughout the Italian territory. Hence an HRAM field test was performed in July 2000 in Friuli, North-Eastern Italy to assess the capabilities and limitations of HRAM over a buried pipeline and a domestic waste site. A Cesium magnetometer in towed bird configuration was used on two separate grids. Profile line spacing was 50-100 m and bird nominal ground clearance was set to 50 m. Microlevelled total field magnetic anomaly data forms the basis for subsequent advanced processing products including 3D analytic signal, maximum horizontal gradient of pseudo-gravity and 3D Euler Deconvolution. The magnetic signatures we detected and enhanced over the environmental test site area in Friuli are also compared with similar but more extensive HRAM signatures recently observed in other countries

GISEA: an Italian biological agents registry in rheumatology

The GISEA registry is an independent database that was established by the Italian Group for the Study of Early Arthritis (GISEA) in 2008, funded by the Italian Association of Rheumatic Patients (ANMAR - ONLUS). In line with the network's epidemiological strategy, the initial protocol was designed to collect long-term follow-up data concerning patients with rheumatic diseases treated with biological agents in order to investigate the realworld characteristics in terms of disease activity, comorbidities and survival on treatment. We here describe the design and methodology used to collect patient data. Information concerning demographics, disease activity, treatment changes (including the reasons for changing and the duration of each therapy), concomitant therapies and adverse events is available to all the members of the study groups by means of a web-based interface that allows queries and the presentation of numerical data, as well as graphics to illustrate trends. Fourteen Italian rheumatology centres have contributed patients to the database which, at the time writing, includes 5145 patients (72% women) with a mean age of 53 years (range 16-88). The initial diagnoses were rheumatoid arthritis (3494 patients, 67.9%), psoriatic arthritis (833, 16.2%), ankylosing spondylitis (493, 9.6%), undifferentiated spondylo-arthritides (307, 5.9%), enteropathic arthritis (14, 0.3%) and spondylitis following reactive arthritis (4, 0.1%). These patients have been followed for up to 10 years, and 1927 (35.8%) have been treated for at least three years. The biological treatments received include etanercept, infliximab, anakinra, adalimumab, abatacept, rituximab and tocilizumab. A total of 2926 adverse events have been observed, with 1171 patients (22%) reporting at least one. Analysis of the accumulated data will provide insights into the critical early phase of the studied arthritides, and enable us to identify the clinical and laboratory profiles that may predict responsiveness to a specific therapy

Imaging bedrock topography and geological controls on ice streams flowing in the Wilkes Subglacial Basin sector of East Antarctica

The northern Wilkes Subglacial Basin (NWSB) in East Antarctica underlies the catchments of the Matusevich, Cook, Ninnis and Mertz Glaciers, which are largely marine-based and hence particularly sensitive to past and future ocean and climate warming. Here we use airborne radar, aeromagnetic and airborne gravity data to image bedrock topography, subglacial geology and deeper crustal structure and assess its influence on ice sheet dynamics in the NWSB. The previously identified Central Basins extend beneath the fast flowing Cook ice streams, indicating that potential ocean-induced changes could propagate further into the interior of the ice sheet. By analogy with the better exposed Rennick Graben in northern Victoria Land, these deep subglacial basins are interpreted here as grabens that steer fast glacial flow. With the aid of depth to source estimates and forward magnetic and gravity models, we image the 3D variability in geological basal boundary conditions, including Beacon sediments and Jurassic basaltic rocks and uplifted basement blocks within and along the flanks of these grabens. A remarkable contrast in magnetic anomaly signatures is observed over the coastal and inland segments of the Cook ice stream catchment. We model several km thick early Cambrian to late Neoproterozoic sedimentary basins in the basement of the coastal region, in contrast to a prominent Proterozoic basement high at the onset of fast glacial flow further inland. We further hypothesise that this difference affects geothermal heat flux at the base of the ice sheet, which could in turn influence basal melting and subglacial hydrology

High geothermal heat flow beneath Thwaites Glacier in West Antarctica inferred from aeromagnetic data

Geothermal heat flow in the polar regions plays a crucial role in understanding ice-sheet dynamics and predictions of sea level rise. Continental-scale indirect estimates often have a low spatial resolution and yield largest discrepancies in West Antarctica. Here we analyse geophysical data to estimate geothermal heat flow in the Amundsen Sea Sector of West Antarctica. With Curie depth analysis based on a new magnetic anomaly grid compilation, we reveal variations in lithospheric thermal gradients. We show that the rapidly retreating Thwaites and Pope glaciers in particular are underlain by areas of largely elevated geothermal heat flow, which relates to the tectonic and magmatic history of the West Antarctic Rift System in this region. Our results imply that the behavior of this vulnerable sector of the West Antarctic Ice Sheet is strongly coupled to the dynamics of the underlying lithosphere

A high-resolution aeromagnetic survey over the Cape Roberts Rift Basin: Correlations with seismic reflection and magnetic susceptibility log data

A high-resolution aeromagnetic survey (altitude 125 m asl, spacing 500 m , area 800 km2) was carried out in 1994 offshore of Cape Roberts by the GITARA (German ITalian Aeromagnetic Research in Antarctica) Group. The availability from drilling of whole-core physical properties logs for magnetic susceptibility, P-wave velocity and density/porosity data allows new insights to be inferred from reprocessed and reviewed HRAM aeromagnetic data. Aeromagnetic data have been reprocessed to image with greater detail the structural framework along the western flank of the Victoria Land Basin. New processing includes 2D Werner and 3D Euler deconvolution, the production of maps of the maximum horizontal gradient of pseudo-gravity, and 2D, 3D modelling. Magnetic trends and anomalies are discussed in conjunction with now available drilling results from the CRP, existing bathymetric data and recently published interpretations of a multichannel seismic reflection survey

Moho depths of Antarctica: comparison of seismic, gravity, and isostatic results

The lithospheric structure of Antarctica is still under‐explored. Moho depth estimate studies are in disagreement by more than 10 km in several regions, including for example the hinterland of the Transantarctic Mountains. Taking account the sparseness of seismological stations and the non‐uniqueness of potential field methods, inversions of Moho depth are performed here based on satellite gravity data in combination with currently available seismically constrained Moho depth estimates. Our results confirm that a lower density contrast at the Moho is present under East Antarctica than beneath West Antarctica. A comparison between the Moho depth derived from our inversion and an Airy‐isostatic Moho model also reveals a spatially variable buoyancy contribution from the lithospheric mantle beneath contrasting sectors of East Antarctica. Finally, to test the plausibility of different Moho depths scenarios for the Transantarctic Mountains–Wilkes Subglacial Basin system, we present 2‐D lithospheric models along the TAMSEIS/GAMSEIS seismic profile. Our models show that if a moderately depleted lithospheric mantle of inferred Proterozoic age underlies the region, then a shallower Moho is more likely beneath the Wilkes Subglacial Basin. If however, re‐fertilisation processes occurred in the upper mantle, for example in response to Ross‐age subduction, then a deeper Moho scenario is preferred. We conclude that 3D lithospheric modeling, coupled with the availability of new seismic information in the hinterland of the Transantarctic Mountains is required to help resolve this controversy, thereby also reducing the ambiguities in geothermal heat flux estimation beneath this key part of the East Antarctic Ice Sheet

The Paleocene of Antarctica: dinoflagellate cyst biostratigraphy, chronostratigraphy and implications for the palaeo-Pacific margin of Gondwana

The Paleocene (66–56 Ma) was a critical time interval for understanding recovery from mass extinction in high palaeolatitudes when global climate was warmer than today. A unique sedimentary succession from Seymour Island (Antarctic Peninsula) provides key reference material from this important phase of the early Cenozoic. Dinoflagellate cyst data from a 376 m thick stratigraphical section, including the Cretaceous–Paleogene boundary, is correlated with biozones from New Zealand, the East Tasman Plateau and southeastern Australia. A detailed age model is suggested for the López de Bertodano (LDBF) and Sobral (SF) formations based on dinoflagellate cyst biostratigraphy and U-Pb dating of zircons, supported by correlated magnetostratigraphy and strontium isotope values from macrofossils. The top of the LDBF is confirmed as latest Maastrichtian to earliest Danian (~ 66.2–65.65 Ma) in age. The overlying SF is mostly Danian in age, with an inferred hiatus near the top overlain by sediments dated as? late Thanetian. Rare Apectodinium homomorphum first appear in the uppermost SF; the first in situ record from Antarctica. The distribution of marine and terrestrial fossils from uppermost Cretaceous to Eocene sediments in Patagonia, Antarctica, New Zealand and Australia required both sea and land connections between these fragments of Gondwana. Fossil evidence and reconstructions of Antarctic palaeogeography and palaeotopography reveals evidence for persistent embayments in the proto-Weddell and Ross Sea regions at this time. We conclude that a coastal dispersal route along the palaeo-Pacific margin of Gondwana could explain the fossil distribution without requiring a transAntarctic strait or closely spaced archipelago. A region in the West to East Antarctic boundary zone, elevated until the early Paleogene, perhaps acted as a site for high elevation ice caps. This supports fossil, geochemical and sedimentological evidence for cold climate intervals and significant sea level falls during the Maastrichtian and Paleocene

Thymosin β4 and β10 in Sjögren's syndrome: Saliva proteomics and minor salivary glands expression

Background: In the present study, we investigated whether thymosin β (Tβ) in saliva and in minor salivary glands is differentially expressed in patients with primary Sjögren's syndrome (pSS) and patients with autoimmune diseases (systemic sclerosis [SSc], systemic lupus erythematosus [SLE], and rheumatoid arthritis [RA], with and without sicca syndrome [ss]). Methods: Saliva specimens of nine patients with pSS, seven with ss/SSc, seven with ss/SLE, seven with ss/RA, seven with SSc, seven with SLE, and seven with RA, as well as ten healthy subjects, were analyzed using a high-performance liquid chromatograph coupled with a mass spectrometer equipped with an electrospray ionization source to investigate the presence and levels of Tβ4, Tβ4 sulfoxide, and Tβ10. Immunostaining for Tβ4 and Tβ10 was performed on minor salivary glands of patients with pSS and ss. Results: Tβ4 levels were statistically higher in patients with pSS with respect to the other subgroups. Tβ10 was detectable in 66.7 % of patients with pSS and in 42.8 % of those with ss/SSc, while Tβ4 sulfoxide was detectable in 44.4 % of patients with pSS and in 42.9 % of those with ss/SSc. Tβ10 and Tβ4 sulfoxide were not detectable in patients without associated ss and in healthy control subjects. Regarding thymosin immunostaining, all patients had immunoreactivity for Tβ10, and a comparable distribution pattern in the four different subgroups of patients was observed. Tβ4 immunoreactivity was present in patients with ss/SSc and those with ss/SLE, while it was completely absent in patients with pSS and those with ss/RA. Conclusions: Our data show that higher salivary Tβ expression characterizes patients with pSS, while Tβ4 sulfoxide and Tβ10 salivary expression was selectively present in patients with sicca symptoms. Moreover, at the immunohistochemical level in patients with pSS, minor salivary glands showed a peculiar pattern characterized by immunostaining for Tβ10 in acinar cells in the absence of any reactivity for Tβ4. These findings, taken together, suggest a different role for Tβ4 and Tβ10 in patients with pSS who have ss and other autoimmune disease